Highland Laboratories - Red Red Wine™ Resveratrol - 120 lozenges

Other Ingredients: Xylitol, fructose, cellulose, palm kernel stearate, natural flavor, and silica.

Does Not Contain: Alcohol, corn, soy, salt, yeast, gluten, milk & egg products, sucrose, starch, MSG, or preservatives.

Suggested Usage: Take 1-2 lozenges and allow to dissolve completely in your mouth, or as directed by your qualified health consultant.
Allowing the lozenge(s) to dissolve for at least 60 seconds, increases tissue absorption directly into the circulatory system, which greatly increases plasma levels of Resveratrol in the body.

Cautions: Keep out of the reach of children.
Store in a cool, dry place.

Description: * Red Red Wine™ Resveratrol Lozenges

Resveratrol: Activating Longevity?

First discovered in 1940, the polyphenolic flavonoid resveratrol (that protects plants from UV damage and attack from pathogens or fungi) became an immediate media sensation in 1992 when it was found in wine grapes. It was instantly linked to the cardioprotective effects of red wine – the so-called French paradox. But much has been learned about resveratrol in the last several decades, and, surprisingly, the major discoveries have slipped quietly under the radar.

The discoveries came about because scientists are not only interested in what a nutrient can do, but they also want to understand its “mechanism of action,” or how it works. This is where the resveratrol story gets really exciting. Researchers have found that resveratrol revs up “survival” enzymes (sirtuins) in our cells. Discovered in 2003, sirtuins enhance cell survival in times of stress: they halt the normal cycle that typically ends with cellular suicide, and instead beef up the cell’s DNA repair process and stimulate the production of antioxidants that rejuvenate it.

Sirtuins spring to action particularly when there is a shortage of food, and may explain the connection between calorie restriction and improved longevity. Scientists have known for years that calorie reduction of approximately 30% coupled with a nutritious diet can increase lifespan up to 50% in various species, including flies, worms and mice. Research suggests that when calories drop, sirtuins boosts cellular respiration, which is the process of converting calories into energy. Along with increasing lifespan, calorie restriction and the resulting sirtuins also play a role in ameliorating diseases of aging – like type 2 diabetes – by improving glucose homeostasis and insulin sensitivity.1 Researchers have been studying the effect of sirtuins on other metabolic diseases, as well, including diet-induced obesity and non-alcoholic fatty liver disease.2

What does this have to do with resveratrol? That is why this story is exciting. Resveratrol has been found to activate sirtuins,3 triggering many of the same biochemical effects as calorie restriction – without the calorie restriction. Studies on mice, for example, demonstrate that including resveratrol in a high fat diet ameliorates insulin resistance.4 Another mouse study created a high fat diet (60% of energy from fat) by adding hydrogenated coconut oil to a standard diet. The high-fat diet mice consumed about 30% more calories than mice on the standard diet. Researchers found that mice fed the standard diet and those on the high-fat diet plus 22 mg/kg resveratrol had a 30% lower risk of death than the mice on just the high-fat diet.5 Still more research shows that resveratrol mimics the health benefits of calorie restriction by enhancing cell mitochondria functioning, improving metabolic signaling pathways, and inhibiting pro-inflammatory pathways in mice fed a high-calorie, high-fat diet.6 Consider the health-promoting impact that resveratrol could have not only with overweight and diabetic individuals, but also with those who aren’t faced with these health issues.

So if resveratrol turns on the longevity enzymes, our goal should be to get enough resveratrol into the diet. While it’s found in the skins of berries and grapes, it isn’t present in quantities that have a desired impact. In fact, an expert on a documentary suggested we’d need to consume 1,000 bottles of red wine daily to get adequate longevity protection from resveratrol! Resveratrol supplements are the obvious solution, but some delivery methods are more effective than others. A small study found that absorption is greater holding resveratrol in the mouth for 60 seconds, much like savoring a good glass of red wine. That would mean holding 1.25 mg of resveratrol in the mouth for 60 seconds provides the equivalent plasma level of resveratrol as swallowing a 300 mg capsule or tablet. Tastes better too!

That’s why we created our Red, Red Wine™ Resveratrol Lozenge. Unlike other supplements using Japanese Knotweed as a source of resveratrol, we use French wine extract in our formula because that’s the source used for all the relevant resveratrol studies. Think of it: all the benefits of red wine without the alcohol!

While scientists continue to study the benefits of resveratrol and sirtuins, at least one major pharmaceutical firm has spent three quarters of a billion dollars to create a patentable drug. Drugs are one option. A great tasting everyday lozenge is another.

References:

1 Smith, JJ, et al. “Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.” BMC Syst Biol 3 (2009): 31.

2 Chaudhary, N and PT Pfluger. “Metaoblic benefits from SIRT1 and SIRT1 activators.” Curr Opin Clin Nutr Metab Care 12.4 (2009): 431-7.

3 Marques, FZ, et al. “Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits.” J Biochem Cell Biol 12 Jun. 2009.

4 Jiang, WJ. “Sirtuins: novel targets for metabolic disease in drug development.” Biochem Biophys Res Commun 373.3 (2008): 341-4.

5 Baur, J, et al. “Resveratrol improves health and survival of mice on a high-calorie diet” Nature 444 16 Nov. 2006: 337-342.

6 Smith, JJ, et al. “Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.” BMC Syst Biol 3 (2009): 31.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Highland Laboratories

P.O. Box 199
110 South Garfield
Mt. Angel, OR. 97362
503-845-9223
fax 503-845-2093
e-mail: sales@highlandvitamins.com
website: www.highlandvitamins.com